Graphene corneal contact lens provides robust, irritation-free topographic electroretinography

Home / News / Graphene corneal contact lens provides robust, irritation-free topographic electroretinography

Our vision can be damaged or lost by damage to the retina—a sensory membrane lining the back of the eye that senses light, converting the image formed into electrochemical neuronal signals—resulting from two classes of medical conditions: a number of inherited degenerative conditions—including retinitis pigmentosa, Leber’s congenital amaurosis, cone dystrophy, and Usher Syndrome—as well as diabetic retinopathy, central retinal vein occlusion, sickle cell retinopathy, toxic an autoimmune retinopathies, retinal detachment, and other ocular disorders.

To be properly diagnosed and treated (especially when a cataract compromises ophthalmoscopy, 2-D fundus photography, 3-D optical coherence tomography, and other retinal imagery tools), such medical conditions rely on electroretinography—a sensitive technique that detects and measures electrical potential changes at the eye’s corneal surface produced in response to a light stimulus by neuronal and non-neuronal retinal cells. Nevertheless, electroretinography has historically faced challenges in the ocular interface electrodes needed to detect an electroretinogram (ERG), these being patient discomfort due to hard electrodes, limited types of electroretinograms with a single type of electrode, reduced signal amplitudes and stability, and excessive eye movement.

Recently, however, scientists at Peking University, Beijing, have demonstrated soft, transparent GRAphene Contact lens Electrodes (GRACEs) for conformal full-cornea electroretinogram signal recording in rabbits and cynomolgus monkeys, showing that their soft graphene contact lens electrodes address these limitations.

Prof. Xiaojie Duan discussed the paper that she, graduate students and lead authors Rongkang Yin and Zheng Xu, and their co-authors published in Nature Communications. The biggest challenge in fabricating soft electrodes with broad-spectrum optical transparency, Dr. Duan told, was fabricating wrinkle-free contact lens electrodes, explaining that wrinkles can cause optical inhomogeneity across the , thereby affecting ocular refraction and the accuracy of the light stimulus pattern on the retina. “This in turn undercuts retinopathy diagnosis efficacy,” Dr. Duan added. “Graphene obtained from conventional growth method is a flat film, and wrinkles inevitably form after transferring the flat graphene film to the curved surface. To make a graphene contact lens electrode with high electrical conductivity and optical uniformity across the electrode, it’s important to directly use a curved graphene film with uniform thickness.” Read full article here.


About the National Graphene Association (NGA)

The National Graphene Association is the main organization and body in the U.S. advocating and promoting the commercialization of graphene. NGA is focused on addressing critical issues such as policy and standards development that will result in effective integration of graphene and graphene-based materials globally. NGA brings together current and future graphene stakeholders — entrepreneurs, companies, researchers, developers and suppliers, investors, venture capitalists, and government agencies — to drive innovation, and to promote and facilitate the commercialization of graphene products and technologies. Join NGA here.


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